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|000006e0| 65 6c 70 68 69 61 3b 20 | 54 65 6d 70 6c 65 20 55 |elphia; |Temple U|
|000006f0| 6e 69 76 7d 0d 0a 24 4a | 6f 75 72 6e 61 6c 7b 4a |niv}..$J|ournal{J|
|00000700| 20 50 65 64 69 61 74 72 | 7d 0d 0a 24 56 6f 6c 75 | Pediatr|}..$Volu|
|00000710| 6d 65 7b 31 31 33 7d 0d | 0a 24 50 61 67 65 7b 39 |me{113}.|.$Page{9|
|00000720| 39 36 2d 31 30 30 31 7d | 0d 0a 24 44 61 74 65 7b |96-1001}|..$Date{|
|00000730| 44 65 63 65 6d 62 65 72 | 20 31 39 38 38 7d 0d 0a |December| 1988}..|
|00000740| 24 59 42 56 6f 6c 7b 31 | 39 39 30 20 59 65 61 72 |$YBVol{1|990 Year|
|00000750| 20 42 6f 6f 6b 20 6f 66 | 20 50 65 64 69 61 74 72 | Book of| Pediatr|
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|00000770| 30 2d 31 30 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |0-10}..$|YBEditor|
|00000780| 7b 44 72 73 2e 20 4f 73 | 6b 69 20 61 6e 64 20 53 |{Drs. Os|ki and S|
|00000790| 74 6f 63 6b 6d 61 6e 7d | 0d 0a 24 54 61 62 6c 65 |tockman}|..$Table|
|000007a0| 7b 7d 0d 0a 24 43 6f 6d | 6d 65 6e 74 61 74 6f 72 |{}..$Com|mentator|
|000007b0| 7b 54 2e 52 2e 20 57 65 | 6c 63 68 2c 20 4d 2e 44 |{T.R. We|lch, M.D|
|000007c0| 2e 7d 0d 0a 0d 0a 43 6f | 70 79 72 69 67 68 74 20 |.}....Co|pyright |
|000007d0| 28 63 29 20 59 65 61 72 | 62 6f 6f 6b 20 4d 65 64 |(c) Year|book Med|
|000007e0| 69 63 61 6c 20 50 75 62 | 6c 69 73 68 65 72 73 2c |ical Pub|lishers,|
|000007f0| 20 49 6e 63 2e 2c 20 31 | 39 39 30 0d 0a 0d 0a 31 | Inc., 1|990....1|
|00000800| 39 39 30 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |990 Year| Book of|
|00000810| 20 50 65 64 69 61 74 72 | 69 63 73 20 28 52 29 0d | Pediatr|ics (R).|
|00000820| 0a 0d 0a 43 68 61 70 74 | 65 72 20 31 30 2d 2d 54 |...Chapt|er 10--T|
|00000830| 68 65 20 47 65 6e 69 74 | 6f 75 72 69 6e 61 72 79 |he Genit|ourinary|
|00000840| 20 54 72 61 63 74 0d 0a | 0d 0a 2d 2d 2d 2d 2d 2d | Tract..|..------|
|00000850| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00000890| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 50 72 65 64 69 63 |--------|..Predic|
|000008a0| 74 69 6e 67 20 74 68 65 | 20 52 65 73 70 6f 6e 73 |ting the| Respons|
|000008b0| 65 20 74 6f 20 43 79 74 | 6f 74 6f 78 69 63 20 54 |e to Cyt|otoxic T|
|000008c0| 68 65 72 61 70 79 20 66 | 6f 72 20 43 68 69 6c 64 |herapy f|or Child|
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|000008e0| 79 6e 64 72 6f 6d 65 3a | 0d 0a 53 75 70 65 72 69 |yndrome:|..Superi|
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|00000910| 6f 69 64 20 54 68 65 72 | 61 70 79 20 4f 76 65 72 |oid Ther|apy Over|
|00000920| 20 48 69 73 74 6f 70 61 | 74 68 6f 6c 6f 67 69 63 | Histopa|thologic|
|00000930| 0d 0a 50 61 74 74 65 72 | 6e 73 0d 0a 0d 0a 53 63 |..Patter|ns....Sc|
|00000940| 68 75 6c 6d 61 6e 20 53 | 4c 2c 20 4b 61 69 73 65 |hulman S|L, Kaise|
|00000950| 72 20 42 41 2c 20 50 6f | 6c 69 6e 73 6b 79 20 4d |r BA, Po|linsky M|
|00000960| 53 2c 20 53 72 69 6e 69 | 76 61 73 61 6e 20 52 2c |S, Srini|vasan R,|
|00000970| 20 42 61 6c 75 61 72 74 | 65 20 48 4a 0d 0a 28 53 | Baluart|e HJ..(S|
|00000980| 74 20 43 68 72 69 73 74 | 6f 70 68 65 72 27 73 20 |t Christ|opher's |
|00000990| 48 6f 73 70 20 66 6f 72 | 20 43 68 69 6c 64 72 65 |Hosp for| Childre|
|000009a0| 6e 2c 20 50 68 69 6c 61 | 64 65 6c 70 68 69 61 3b |n, Phila|delphia;|
|000009b0| 20 54 65 6d 70 6c 65 20 | 55 6e 69 76 29 0d 0a 4a | Temple |Univ)..J|
|000009c0| 20 50 65 64 69 61 74 72 | 20 31 31 33 3a 39 39 36 | Pediatr| 113:996|
|000009d0| 2d 31 30 30 31 2c 20 44 | 65 63 65 6d 62 65 72 20 |-1001, D|ecember |
|000009e0| 31 39 38 38 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1988..--|--------|
|000009f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a30| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|00000a40| 0d 0a 0d 0a 20 20 20 20 | 20 43 6f 6e 74 72 6f 76 |....    | Controv|
|00000a50| 65 72 73 79 20 65 78 69 | 73 74 73 20 72 65 67 61 |ersy exi|sts rega|
|00000a60| 72 64 69 6e 67 20 74 68 | 65 20 76 61 6c 75 65 20 |rding th|e value |
|00000a70| 6f 66 20 72 65 6e 61 6c | 20 62 69 6f 70 73 79 20 |of renal| biopsy |
|00000a80| 62 65 66 6f 72 65 20 69 | 6e 69 74 69 61 74 69 6e |before i|nitiatin|
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|00000aa0| 67 20 74 68 65 72 61 70 | 79 20 69 6e 20 61 20 63 |g therap|y in a c|
|00000ab0| 68 69 6c 64 20 77 69 74 | 68 20 73 74 65 72 6f 69 |hild wit|h steroi|
|00000ac0| 64 2d 73 65 6e 73 69 74 | 69 76 65 20 62 75 74 20 |d-sensit|ive but |
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|00000ae0| 70 73 69 6e 67 20 6e 65 | 70 68 72 6f 74 69 63 20 |psing ne|phrotic |
|00000af0| 73 79 6e 64 72 6f 6d 65 | 20 6f 72 20 77 69 74 68 |syndrome| or with|
|00000b00| 20 73 74 65 72 6f 69 64 | 2d 64 65 70 65 6e 64 65 | steroid|-depende|
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|00000b30| 74 72 6f 73 70 65 63 74 | 69 76 65 20 73 74 75 64 |trospect|ive stud|
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|00000b50| 65 63 69 6d 65 6e 73 20 | 66 72 6f 6d 20 39 32 20 |ecimens |from 92 |
|00000b60| 63 68 69 6c 64 72 65 6e | 20 61 67 65 64 20 31 2d |children| aged 1-|
|00000b70| 31 36 20 79 65 61 72 73 | 0d 0a 77 65 72 65 20 65 |16 years|..were e|
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|00000c40| 72 65 6c 61 70 73 65 72 | 20 61 73 20 64 65 66 69 |relapser| as defi|
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|00000c60| 72 6e 61 74 69 6f 6e 61 | 6c 20 53 74 75 64 79 20 |rnationa|l Study |
|00000c70| 6f 66 20 4b 69 64 6e 65 | 79 20 44 69 73 65 61 73 |of Kidne|y Diseas|
|00000c80| 65 20 69 6e 20 43 68 69 | 6c 64 72 65 6e 2c 20 77 |e in Chi|ldren, w|
|00000c90| 65 72 65 20 63 6f 72 72 | 65 6c 61 74 65 64 20 77 |ere corr|elated w|
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|00000cc0| 54 68 65 20 6d 65 61 6e | 20 66 6f 6c 6c 6f 77 2d |The mean| follow-|
|00000cd0| 75 70 20 77 61 73 20 37 | 2e 32 20 79 65 61 72 73 |up was 7|.2 years|
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|00000d10| 63 6c 65 72 6f 73 69 73 | 20 69 6e 20 33 39 20 63 |clerosis| in 39 c|
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|00000d30| 0a 6e 65 70 68 72 6f 73 | 69 73 20 69 6e 20 32 38 |.nephros|is in 28|
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|00000d50| 6c 65 20 66 69 6e 64 69 | 6e 67 73 20 69 6e 20 32 |le findi|ngs in 2|
|00000d60| 35 2e 20 20 54 68 65 72 | 65 20 77 61 73 20 73 74 |5.  Ther|e was st|
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|00002140| 0d 0a 0d 0a 43 68 61 70 | 74 65 72 20 31 30 2d 2d |....Chap|ter 10--|
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|00002290| 39 3a 39 31 33 2d 39 31 | 38 2c 20 4f 63 74 20 36 |9:913-91|8, Oct 6|
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|000022b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00003730| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003740| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003750| 0d 0a 4c 61 62 6f 72 61 | 74 6f 72 79 20 61 6e 64 |..Labora|tory and|
|00003760| 20 43 6c 69 6e 69 63 61 | 6c 20 56 61 72 69 61 62 | Clinica|l Variab|
|00003770| 6c 65 73 20 74 6f 20 50 | 72 65 64 69 63 74 20 4f |les to P|redict O|
|00003780| 75 74 63 6f 6d 65 20 69 | 6e 20 48 65 6d 6f 6c 79 |utcome i|n Hemoly|
|00003790| 74 69 63 2d 55 72 65 6d | 69 63 0d 0a 53 79 6e 64 |tic-Urem|ic..Synd|
|000037a0| 72 6f 6d 65 0d 0a 0d 0a | 48 61 76 65 6e 73 20 50 |rome....|Havens P|
|000037b0| 4c 2c 20 4f 27 52 6f 75 | 72 6b 65 20 50 50 2c 20 |L, O'Rou|rke PP, |
|000037c0| 48 61 68 6e 20 4a 2c 20 | 48 69 67 67 69 6e 73 20 |Hahn J, |Higgins |
|000037d0| 4a 2c 20 57 61 6c 6b 65 | 72 20 41 4d 0d 0a 28 43 |J, Walke|r AM..(C|
|000037e0| 68 69 6c 64 72 65 6e 27 | 73 20 48 6f 73 70 2c 20 |hildren'|s Hosp, |
|000037f0| 42 6f 73 74 6f 6e 3b 20 | 48 61 72 76 61 72 64 20 |Boston; |Harvard |
|00003800| 53 63 68 6f 6f 6c 20 6f | 66 20 50 75 62 6c 69 63 |School o|f Public|
|00003810| 20 48 65 61 6c 74 68 2c | 20 42 6f 73 74 6f 6e 29 | Health,| Boston)|
|00003820| 0d 0a 41 6d 20 4a 20 44 | 69 73 20 43 68 69 6c 64 |..Am J D|is Child|
|00003830| 20 31 34 32 3a 39 36 31 | 2d 39 36 34 2c 20 53 65 | 142:961|-964, Se|
|00003840| 70 74 65 6d 62 65 72 20 | 31 39 38 38 0d 0a 2d 2d |ptember |1988..--|
|00003850| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003860| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003870| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003880| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003890| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|000038a0| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|....    |
|000038b0| 20 49 6d 70 72 6f 76 65 | 6d 65 6e 74 73 20 69 6e | Improve|ments in|
|000038c0| 20 64 69 61 6c 79 73 69 | 73 20 61 6e 64 20 67 65 | dialysi|s and ge|
|000038d0| 6e 65 72 61 6c 20 70 61 | 74 69 65 6e 74 20 63 61 |neral pa|tient ca|
|000038e0| 72 65 20 68 61 76 65 20 | 72 65 64 75 63 65 64 20 |re have |reduced |
|000038f0| 74 68 65 0d 0a 6d 6f 72 | 74 61 6c 69 74 79 20 72 |the..mor|tality r|
|00003900| 61 74 65 20 69 6e 20 70 | 61 74 69 65 6e 74 73 20 |ate in p|atients |
|00003910| 77 69 74 68 20 68 65 6d | 6f 6c 79 74 69 63 2d 75 |with hem|olytic-u|
|00003920| 72 65 6d 69 63 20 73 79 | 6e 64 72 6f 6d 65 20 28 |remic sy|ndrome (|
|00003930| 48 55 53 29 2c 20 62 75 | 74 0d 0a 73 69 67 6e 69 |HUS), bu|t..signi|
|00003940| 66 69 63 61 6e 74 20 6d | 6f 72 62 69 64 69 74 79 |ficant m|orbidity|
|00003950| 20 73 74 69 6c 6c 20 6f | 63 63 75 72 73 20 69 6e | still o|ccurs in|
|00003960| 20 31 30 25 20 74 6f 20 | 32 30 25 20 6f 66 20 70 | 10% to |20% of p|
|00003970| 61 74 69 65 6e 74 73 20 | 77 69 74 68 20 63 68 72 |atients |with chr|
|00003980| 6f 6e 69 63 0d 0a 72 65 | 6e 61 6c 20 66 61 69 6c |onic..re|nal fail|
|00003990| 75 72 65 20 28 43 52 46 | 29 2c 20 68 79 70 65 72 |ure (CRF|), hyper|
|000039a0| 74 65 6e 73 69 6f 6e 2c | 20 6f 72 20 73 65 76 65 |tension,| or seve|
|000039b0| 72 65 20 6e 65 75 72 6f | 6c 6f 67 69 63 20 73 65 |re neuro|logic se|
|000039c0| 71 75 65 6c 61 65 2e 20 | 20 41 0d 0a 70 72 6f 67 |quelae. | A..prog|
|000039d0| 6e 6f 73 74 69 63 20 67 | 75 69 64 65 20 77 61 73 |nostic g|uide was|
|000039e0| 20 64 65 76 65 6c 6f 70 | 65 64 2c 20 75 73 69 6e | develop|ed, usin|
|000039f0| 67 20 6f 62 6a 65 63 74 | 69 76 65 20 63 72 69 74 |g object|ive crit|
|00003a00| 65 72 69 61 20 61 76 61 | 69 6c 61 62 6c 65 20 77 |eria ava|ilable w|
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|00003a20| 20 34 38 20 68 6f 75 72 | 73 20 6f 66 20 68 6f 73 | 48 hour|s of hos|
|00003a30| 70 69 74 61 6c 69 7a 61 | 74 69 6f 6e 2c 20 74 68 |pitaliza|tion, th|
|00003a40| 61 74 20 63 6f 75 6c 64 | 20 69 64 65 6e 74 69 66 |at could| identif|
|00003a50| 79 20 70 61 74 69 65 6e | 74 73 20 77 69 74 68 20 |y patien|ts with |
|00003a60| 48 55 53 20 61 74 0d 0a | 68 69 67 68 20 72 69 73 |HUS at..|high ris|
|00003a70| 6b 20 6f 66 20 64 65 61 | 74 68 2c 20 43 52 46 2c |k of dea|th, CRF,|
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|00003aa0| 0d 0a 20 20 20 20 20 54 | 77 6f 20 6f 75 74 63 6f |..     T|wo outco|
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|00003ac0| 20 6f 6e 20 63 6f 6e 64 | 69 74 69 6f 6e 20 61 74 | on cond|ition at|
|00003ad0| 20 68 6f 73 70 69 74 61 | 6c 20 64 69 73 63 68 61 | hospita|l discha|
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|00003b70| 63 6f 6d 65 22 20 67 72 | 6f 75 70 20 69 6e 63 6c |come" gr|oup incl|
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|00003bc0| 61 65 20 6f 6e 20 64 69 | 73 63 68 61 72 67 65 2e |ae on di|scharge.|
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|00003bf0| 64 75 72 61 74 69 6f 6e | 20 6f 66 20 64 69 61 6c |duration| of dial|
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|00003c20| 63 6f 6d 6d 6f 6e 20 69 | 6e 20 74 68 65 20 62 61 |common i|n the ba|
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|00003d40| 20 63 61 6c 63 69 75 6d | 20 6c 65 76 65 6c 73 20 | calcium| levels |
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|00003d70| 74 68 65 20 66 69 72 73 | 74 20 34 38 20 68 6f 75 |the firs|t 48 hou|
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|00004890| 20 49 67 47 0d 0a 69 6e | 66 75 73 69 6f 6e 73 2c | IgG..in|fusions,|
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|00004a20| 20 6d 65 61 6e 69 6e 67 | 66 75 6c 20 64 61 74 61 | meaning|ful data|
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|00004ce0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004dd0| 6e 20 4e 65 70 68 72 6f | 6c 20 33 30 3a 32 32 35 |n Nephro|l 30:225|
|00004de0| 2d 32 32 39 2c 20 4f 63 | 74 6f 62 65 72 20 31 39 |-229, Oc|tober 19|
|00004df0| 38 38 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |88..----|--------|
|00004e00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004e20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004e30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00006010| 63 72 65 61 74 69 6e 69 | 6e 65 20 72 61 74 69 6f |creatini|ne ratio|
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|00006030| 64 20 6d 65 61 73 75 72 | 65 6d 65 6e 74 73 20 6f |d measur|ements o|
|00006040| 66 20 75 72 69 6e 65 20 | 70 72 6f 74 65 69 6e 20 |f urine |protein |
|00006050| 65 78 63 72 65 74 69 6f | 6e 2e 0d 0a 54 68 69 73 |excretio|n...This|
|00006060| 20 68 61 73 20 67 72 65 | 61 74 6c 79 20 73 69 6d | has gre|atly sim|
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|00006160| 6e 67 20 75 72 69 6e 65 | 20 73 70 65 63 69 6d 65 |ng urine| specime|
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|00006330| 68 61 76 65 20 61 20 6e | 6f 72 6d 61 6c 20 65 61 |have a n|ormal ea|
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|00006350| 6f 3b 20 74 68 65 0d 0a | 72 61 74 69 6f 20 6f 62 |o; the..|ratio ob|
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|00006390| 61 62 6e 6f 72 6d 61 6c | 20 28 3c 3d 20 38 30 20 |abnormal| (<= 80 |
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|000063b0| 20 30 2e 37 32 20 6d 67 | 2f 6d 67 29 2e 20 20 54 | 0.72 mg|/mg).  T|
|000063c0| 68 65 72 65 20 61 72 65 | 20 6e 6f 74 20 65 6e 6f |here are| not eno|
|000063d0| 75 67 68 20 64 61 74 61 | 20 79 65 74 20 61 63 63 |ugh data| yet acc|
|000063e0| 75 6d 75 6c 61 74 65 64 | 20 74 6f 0d 0a 64 65 74 |umulated| to..det|
|000063f0| 65 72 6d 69 6e 65 20 74 | 68 65 20 69 6d 70 6f 72 |ermine t|he impor|
+--------+-------------------------+-------------------------+--------+--------+